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美國(guó)Seracare鮭腎桿菌陽(yáng)性對(duì)照

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美國(guó)Seracare

這項(xiàng)工作由美國(guó)國(guó)家癌癥研究所(K99CA181352)和美國(guó)癌癥協(xié)會(huì)資助。
當(dāng)前的理論認(rèn)為，情節(jié)記憶的編碼是通過(guò)海馬回路的早期重塑推動(dòng)的，而大腦皮層的重塑發(fā)生幾個(gè)星期到幾個(gè)月以后，才促進(jìn)長(zhǎng)期記憶存儲(chǔ)和回憶。
在本研究中，美國(guó)麻省理工學(xué)院等處的研究人員利用全基因組RNA測(cè)序，超微結(jié)構(gòu)成像和全細(xì)胞記錄在野生型小鼠平行研究表明，經(jīng)歷了恐懼條件作用的小鼠改變了基因轉(zhuǎn)錄，突觸活動(dòng)增加，并且大腦的中前額皮層(mPFC)區(qū)域內(nèi)的可塑性增加，而抑制中前額皮層(mPFC)神經(jīng)元能削弱長(zhǎng)期記憶的形成，這提示了中前額皮層(mPFC)內(nèi)的早期變化可能讓長(zhǎng)期記憶儲(chǔ)存成為可能。
這些結(jié)果表明，長(zhǎng)期情節(jié)記憶的編碼與新皮層回路早期重塑有關(guān)，確定前額葉皮層作為編碼引起的海馬活化和長(zhǎng)期記憶形成的關(guān)鍵調(diào)節(jié)器，以及對(duì)了解健康和患病的大腦狀態(tài)的記憶過(guò)程具有重要意義。
在腫瘤組織中一種名為捎帶細(xì)胞(Piggy-backing Cells)的快速生長(zhǎng)的細(xì)胞往往會(huì)同高度侵襲性的細(xì)胞一起，一旦其到達(dá)機(jī)體的不同部位就會(huì)開(kāi)啟高效的侵襲模式，zui終形成新的腫瘤組織。文章中研究者利用透明斑馬魚(yú)進(jìn)行研究，以便其可以觀察到癌細(xì)胞如何在機(jī)體中移動(dòng)以及如何進(jìn)行侵襲。腫瘤細(xì)胞轉(zhuǎn)移的惡果是造成癌細(xì)胞全身性擴(kuò)散，侵略全身各處的組織器官。因此，想辦法鎖定控制這種轉(zhuǎn)移或者是從一開(kāi)始就阻斷它們的信息傳遞將會(huì)是抗癌路上的一個(gè)突破性進(jìn)展。
比利時(shí)魯汶天主教大學(xué)的研究人員*成功的利用小鼠研究人類(lèi)腫瘤模型，研究結(jié)果發(fā)表在了7月24日的 Cell Report 期刊上。
魯汶天主教大學(xué)實(shí)驗(yàn)和臨床研究中心的 Pierre Sonveaux's 教授帶領(lǐng)及其所帶領(lǐng)的團(tuán)隊(duì)前期對(duì)腫瘤細(xì)胞的線(xiàn)粒體進(jìn)行了深入研究，進(jìn)而成功發(fā)現(xiàn)了一個(gè)化學(xué)藥物家族，發(fā)揮藥效時(shí)能夠防止腫瘤細(xì)胞的轉(zhuǎn)移。他們發(fā)現(xiàn)線(xiàn)粒體這一 “細(xì)胞動(dòng)力工廠”的功能改變時(shí)，會(huì)促進(jìn)腫瘤細(xì)胞的轉(zhuǎn)移。
博士后研究的 Paolo E. Porporato 和 Pierre Sonveaux's 團(tuán)隊(duì)中其他一些年輕的研究人員深入挖掘了線(xiàn)粒體這一功能的分子機(jī)制，zui終發(fā)現(xiàn)是由于線(xiàn)粒體在某些特定情況下，會(huì)產(chǎn)生大量的自由基——超氧化物，正是這些超氧化物的過(guò)剩導(dǎo)致腫瘤細(xì)胞的轉(zhuǎn)移，造成不可挽回的后果。
包括帕金森病和阿爾茨海默氏癥等許多其它人類(lèi)疾病中，線(xiàn)粒體產(chǎn)生的超氧化物都可以被特殊的抗氧化劑所封閉，例如 MitoTEMPO 。小鼠給藥以及人類(lèi)腫瘤模型給藥的結(jié)果均闡明了，這些化合物能夠高效地阻斷腫瘤細(xì)胞的遷移，并且防止小鼠體內(nèi)人類(lèi)腫瘤的自發(fā)形成。

美國(guó)Seracare

我司還提供其它進(jìn)口或國(guó)產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲(chóng)病、違禁品濫用、肺炎球菌、軍團(tuán)菌、食品安全、化妝品檢測(cè)、藥物濫用檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清、德國(guó)SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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【公司名稱(chēng)】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

This work is funded by the National Cancer Institute (K99CA181352) and the American Cancer Society.
Current theory suggests that the encoding of episodic memory is motivated by early remodeling of the hippocampal circuit, and that the remodeling of the cerebral cortex promotes long-term memory storage and recall after only a few weeks to several months.
In this study, researchers at the Massachusetts Institute of Technology and other institutes used genome-wide RNA sequencing, ultrastructural imaging and whole-cell recording in wild-type mice to study in parallel that mice experiencing the fear condition changed gene transcription , An increase in synaptic activity, and an increase in plasticity in the brain's region of the mid-prefrontal cortex (mPFC), while inhibition of mPFC neurons impairs long-term memory formation, suggesting an early phase within the mPFC Changes may make long-term memory storage possible.
These results indicate that long-term episodic memory coding correlates with early remodeling of neocortical circuits, determining the prefrontal cortex as a key regulator of coding-induced hippocampal activation and long-term memory formation, as well as memory processes for understanding healthy and diseased brain states It is of great significance.
In tumor tissue, a rapidly growing cell called Piggy-backing Cells, often with highly aggressive cells, turns on an efficient invasion pattern once it reaches different parts of the body, eventually forming a new tumor organization. In the article, researchers used transparent zebrafish to study how cancer cells can be observed in the body and how they can be infiltrated. Tumor cell metastasis is the result of the spread of cancer cells systemic invasion of tissues and organs throughout the body. Therefore, finding ways to lock in such transfers or blocking their messaging from the outset will be a breakthrough on the road to cancer.
Researchers at the Catholic University of Leuven in Belgium for the first time successfully used mice to study human tumor models, the findings of which were published in the July 24 issue of the Cell Report.
Led by Pierre Sonveaux's professor of the Center for Experimental and Clinical Studies at the Catholic University of Leuven and his team conducted an in-depth study on the mitochondria of tumor cells in advance and successfully discovered a family of chemical drugs that can prevent tumor cell metastasis . They found that when the function of mitochondria, a "cell-powered factory," changed, they promoted tumor cell metastasis.
Paolo E. Porporato, a postdoctoral researcher, and other young researchers at Pierre Sonveaux's team delve into the molecular mechanisms of mitochondrial function, culminating in mitochondria that produce large amounts of free radicals in certain cases Oxides, it is the excess of these superoxides that cause the metastasis of tumor cells, resulting in irreparable consequences.
In many other human diseases, including Parkinson's disease and Alzheimer's disease, the mitochondrial superoxide can be blocked by special antioxidants such as MitoTEMPO. The results of administration to mice as well as administration to human tumor models have demonstrated that these compounds are highly effective at blocking tumor cell migration and prevent the spontaneous formation of human tumors in mice.