美國Seracare彎曲菌屬特異性陽性對照

廣州健侖生物科技有限公司

廣州健侖長期供應各種生物原料，主要代理品牌：美國Seracare、西班牙Certest、美國Fuller等等。

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美國Seracare彎曲菌屬特異性陽性對照

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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美國Seracare

這些開創性的發現，帶領研究人員進入下一個研究階段——如何將這些結果進行轉化，為患者制造更安全和更有效的胰島素產品。zui終目標是，開發新分子形式的胰島素，將確保保護鉸鏈應該打開時才會在胰島素內打開。更新、更有效的胰島素版本令人印象深刻：超*胰島素“智能泵”配方，是美國國立衛生研究院和青少年糖尿病研究基金會(JDRF)的一個戰略目標;胰島素的超穩定模式，將有利于發展中國家制冷條件有限的患者;甚至“聰明”的胰島素分子，當血液中的葡萄糖濃度低于正常時，其會停止工作。胰島素安全和有效性的改善，有望減少糖尿病患者的長期健康后果，如腎衰竭、失明和截肢。
Weiss稱：“我們已經解決了一個現實問題，40多年來對胰島素如何在體內制造的一部分解釋，在準備使用之前，它如何在特異性胰腺β細胞內折疊?如何結合到細胞內的受體?胰島素如何降解?”
對胰島素分子的描述，已經有幾十年的時間，并一直持續到今天：*，研究人員試圖了解，當胰島素存儲在胰腺β細胞內時它看起來像什么。第二，他們需要表明，當胰島素結合到細胞上的胰島素受體時，它看起來像什么。第三，他們想說明，受體如何改變其形狀，響應結合的胰島素，以在細胞內傳輸信號。
加州大學圣地亞哥分校醫學院的研究人員報道稱，膳食辣椒素——辣椒的活性成分，可使小鼠腸道內皮細胞上的一個受體產生慢性活化作用，從而觸發一種反應，zui終降低結直腸癌的風險。相關研究發表在《The Journal of Clinical Investigation》期刊上。
這個受體或離子通道，稱為TRPV1，zui初是在感覺神經元中發現的，在那里它充當環境中高溫、酸度和辛辣化學品的標記。本文資深作者、醫學教授Eyal Raz博士稱：“這些因素，都是對細胞潛在的有害刺激。因此，TRPV1很快被描述為一個分子‘疼痛感受器’。這可被認為是它的常規功能，所有這一切都發生在神經系統中。”
但是，Raz及其同事們發現，TPRV1也在腸道上皮細胞表達，在那里它被表皮生長因子受體(EGFR)激活。EGFR是腸道中細胞增殖的一個重要驅動力，大約每四到六天，腸道上皮層就被替換。
本文*作者Petrus de Jong博士稱：“保持腸道內正常細胞更新，需要一個基本水平的EGFR活性。然而，如果EGFR信號是無限制的，散發性腫瘤的發展風險就會增加。”
科學家們發現，一旦TRPV1被EGFR激活，可引發一種對EGFR的直接負反饋，從而抑制后者降低不必要的生長和腸道腫瘤發展風險。他們發現，缺乏TRPV1的轉基因小鼠，腸道腫瘤的生長率高于正常。

美國Seracare

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、食品安全、化妝品檢測、藥物濫用檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

想了解更多的產品及服務請掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

These groundbreaking findings lead researchers into the next phase of research - how to translate these results into safer and more effective insulin products for patients. The ultimate goal is to develop a new molecular form of insulin that will ensure that the protective hinge should open only in insulin. The newer, more effective version of insulin is impressive: The Super Fast-acting insulin "smart pump" formula is a strategic goal of the National Institutes of Health and the Juvenile Diabetes Research Foundation (JDRF); the ultrastable mode of insulin will benefit Patients in developing countries have limited cooling conditions; even "smart" insulin molecules stop working when blood glucose levels are lower than normal. Improvements in insulin safety and efficacy are expected to reduce long-term health consequences in people with diabetes, such as kidney failure, blindness and amputation.
Weiss said: "We have solved the reality that part of the explanation of how insulin has been made in the body for over 40 years is how it folds within specific pancreatic β-cells before it is ready for use, and how does it bind to intracellular receptors? How to degrade insulin?
The description of insulin molecules has been around for decades and continues today: first, researchers are trying to understand what it looks like when insulin is stored in pancreatic beta cells. Second, they need to show what it looks like when insulin binds to the insulin receptor on the cell. Third, they want to show how receptors change their shape in response to bound insulin to transmit signals inside the cell.
Researchers at the University of California, San Diego School of Medicine reported that the active ingredient of the dietary capsaicin-pepper produces a chronic activation of one of the receptors on mouse intestinal epithelial cells, triggering a response that eventually reduces the risk of colorectal Cancer risk. Related research is published in The Journal of Clinical Investigation.
This receptor or ion channel, called TRPV1, was first found in sensory neurons where it serves as a marker of high temperature, acidity and spicy chemicals in the environment. Dr. Eyal Raz, a senior author and professor of medicine, said: "These are all potentially noxious stimuli on cells and, as a result, TRPV1 is quickly described as a molecule called" pain receptor. "This can be thought of as its usual function, with all It all happens in the nervous system. "
However, Raz and colleagues found that TPRV1 is also expressed in intestinal epithelial cells, where it is activated by the epidermal growth factor receptor (EGFR). EGFR is an important driver of cell proliferation in the gut, and the gut epithelium is replaced every about four to six days.
"The maintenance of normal cell renewal in the intestine requires a basic level of EGFR activity, but if the EGFR signal is unrestricted, the risk of developing sporadic tumors is increased," said lead author Petrus de Jong.
Scientists have found that once TRPV1 is activated by EGFR, it can trigger a direct negative feedback on EGFR, thereby inhibiting the latter from reducing the risk of unnecessary growth and intestinal tumor development. They found that, in the absence of TRPV1 transgenic mice, the growth rate of intestinal tumors was higher than normal.