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博研科研試劑網
博研科研試劑網
Anti-DAXX抗體,死亡相關蛋白6/Fas死亡區相關蛋白抗體，此抗體本公司有單抗和多抗，可用于免疫組化（IHC），免疫印跡（WB），酶聯免疫(ELISA)，IF、IP、流式細胞術等實驗（可來電索取說明）！！
本公司，是專業經營生物試劑，抗體，細胞，標準品，對照品的公司，在廣大用戶的幫助和支持下，經過不懈的努力，已成為國內生命科學領域產品的主要供應商之一，代理許多*水平的高科技產品，包括分子生物學、細胞生物學、免疫學、診斷等多個研究及應用領域。公司的服務和業務網絡遍及全國，在同行獲得*好評。
Anti-DAXX抗體,死亡相關蛋白6/Fas死亡區相關蛋白抗體簡單介紹：
產品別名：BING 2; BING2; DAP 6; DAP6; Death associated protein 6; Fas death domain-associated protein; Death domain associated protein 6; EAP 1; EAP1; ETS1 associated protein 1; Fas death domain associated protein; hDaxx; MGC126245; MGC126246; DAXX_HUMAN.
產品用途：科研實驗
產品編號：BYK-1975R
性 狀：Lyophilized or Liquid
濃 度：1mg/1ml
亞 型：IgG
貯 存：貯存于-20℃.
此抗體本公司有單抗和多抗，可用于免疫組化（IHC），免疫印跡（WB），酶聯免疫(ELISA)，IF、IP、流式細胞術等實驗（可來電索取說明）
相關標記有：Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記
Anti-DAXX抗體,死亡相關蛋白6/Fas死亡區相關蛋白抗體產品說明：Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
連續使用時4°C存儲，保質期六個月補體C1qα鏈多肽抗體*存儲時建議分裝為10ul以上小包裝-20°C存儲，并避免反復凍融，保質期一年。
,死亡相關蛋白6/Fas死亡區相關蛋白抗體相關優質產品：
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