產品新聞

背景資料

Tissue factor is well-known as the main cellular initiator of blood coagulation. The Tissue factor gene encodes coagulation factor III which is a cell surface glycoprotein that enables cells to initiate the blood coagulation cascades， and functions as the high-affinity receptor for the coagulation factor VII. Following vessel injury， the Tissue Factor and Factor VIIa complex activates the coagulation protease cascade， which leads to fibrin deposition and activation of platelets. The ensuing complex presents a catalytic event， which is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Therefore， Tissue factor has a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Tissue Factor can also be stimulated by the inflammatory mediators interleukin 1 and TNF， as well as by endotoxin， to appear on monocytes and vascular endothelial cells as a component of cellular immune response.
Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Certain levels of Tissue Factor are essential for the maintained viability and growth of endothelium and Tissue Factor-expressing tumor cells. Additionally， abnormal Tissue Factor expression inside the vasculature initiates life threatening thrombosis in various diseases， for example sepsis， atherosclerosis， and cancer. Alternative spliced Tissue Factor expression advances tumor growth， and is linked to increased tumor cell proliferation and angiogenesis in pancreatic cancer.

序列

請咨詢我們客服或者請查看品牌*網站

來源宿主

大腸桿菌中重組表達

溶解建議

Sterile Filtered clear solution. Tissue factor protein is supplied in 22mM Tris.HCl pH8.0， 1mM EDTA and 50% glycerol.

保存建議

Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. Please avoid freeze thaw cycles.

其他

ProSpec 是一家全球著名細胞因子蛋白生產和研發的公司，具有20多年的生產經驗，專注于蛋白（重組及合成）生產研發。我們的核心產品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 生產工藝和規模使其可以提供毫克到克級蛋白，價格優于同類公司。絕大部分產品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產品為凍干粉，因此易于運輸和保存。