背景資料

Parathyroid hormone （PTH）， or parathormone， is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calciumin the blood， whereas calcitonin （a hormone produced by the parafollicular cells of the thyroid gland） acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts， which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH； rather， PTH binds to osteoblasts， the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL， which can bind to osteoclast precursors containing RANK， a receptor for RANKL. The binding of RANKL to RANK stimulates these precursors to fuse， forming new osteoclasts which ultimately enhances the resorption of bone.

In the kidney- It enhances active reabsorption of calcium from distal tubules and the thick ascending limb.

In the intestine- It enhances the absorption of calcium in the intestine by increasing the production of vitamin D and upregulating the enzyme responsible for 1-alpha hydroxylationof 25-hydroxy vitamin D， converting vitamin D to its active form （1，25-dihydroxy vitamin D） which effects the actual absorption of calcium （as Ca2+ ions） by the intestine via calbindin.

Recombinant Human full length PTH 1-84 has potential as an anti-osteoporotic agent， due to its properties as a bone formation stimulant， it increases bone turnover， stimulating osteoblasts and reducing both vertebral and non vertebral fractures.

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來(lái)源宿主

大腸桿菌中重組表達(dá)

溶解建議

提供的重組人甲狀旁腺素（1-84）產(chǎn)品為白色無(wú)菌凍干粉末.推薦使用無(wú)菌的18MΩ的超純水來(lái)溶解，濃度不低于100ug/ml，便于后續(xù)稀釋.

保存建議

Lyophilized Parathyrin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution PTH should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專(zhuān)注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類(lèi)公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。