FITC標記的信號轉導銜接結合蛋白抗體產(chǎn)品介紹：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

詳細介紹

英文名稱	Anti-AMSH/FITC
中文名稱	FITC標記的信號轉導銜接結合蛋白抗體
別名	Associated molecule with the SH3 domain of STAM; Endosome associated ubiquitin isopeptidase; Endosome-associated ubiquitin isopeptidase; STABP_HUMAN; STAM binding protein; STAM-binding protein; STAMBP.
說明書	100ul
研究領域	細胞生物細胞周期蛋白結合蛋白表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, Dog, Horse, Rabbit,
產(chǎn)品應用	IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	47kDa
細胞定位	細胞膜
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human AMSH
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹	background: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Subcellular Location: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11. Similarity: Belongs to the peptidase M67C family. Contains 1 MPN (JAB/Mov34) domain.