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當(dāng)前位置：上海泛柯實業(yè)有限公司>>抗體>>一抗>>FITC標(biāo)記的錨蛋白重復(fù)結(jié)構(gòu)域蛋白13A抗體

FITC標(biāo)記的錨蛋白重復(fù)結(jié)構(gòu)域蛋白13A抗體

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更新時間：2015-05-07 15:39:35瀏覽次數(shù)：254次

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商鋪產(chǎn)品：9811條

所在地區(qū)：上海上海

聯(lián)系人：馬經(jīng)理 （銷售專員）

產(chǎn)品簡介

FITC標(biāo)記的錨蛋白重復(fù)結(jié)構(gòu)域蛋白13A抗體產(chǎn)品介紹：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

詳細介紹

英文名稱Anti-ANKRD13A/FITC
中文名稱FITC標(biāo)記的錨蛋白重復(fù)結(jié)構(gòu)域蛋白13A抗體
別    名ANKRD13; ANKRD13A ankyrin repeat domain 13A; ANKRD13A; Ankyrin repeat domain 13; Protein KE03; AN13A_HUMAN.
說 明 書100ul  
研究領(lǐng)域細胞生物  免疫學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Cow, Rabbit, Sheep, 
產(chǎn)品應(yīng)用IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ANKRD13A
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

Subunit:
Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.

Subcellular Location:
Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.

Post-translational modifications:
Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.

Similarity:
Contains 2 ANK repeats.
Contains 3 UIM (ubiquitin-interacting motif) repeats. 


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