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當(dāng)前位置：上海泛柯實(shí)業(yè)有限公司>>抗體>>一抗>>FITC標(biāo)記的未知糖基化轉(zhuǎn)移酶AER61抗體

FITC標(biāo)記的未知糖基化轉(zhuǎn)移酶AER61抗體

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產(chǎn)品簡介

FITC標(biāo)記的未知糖基化轉(zhuǎn)移酶AER61抗體產(chǎn)品介紹：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

詳細(xì)介紹

英文名稱Anti-AER61/FITC
中文名稱FITC標(biāo)記的未知糖基化轉(zhuǎn)移酶AER61抗體
別    名C3orf64; Uncharacterized glycosyltransferase AER61; EOGT_HUMAN.
說 明 書100ul  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  糖蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
產(chǎn)品應(yīng)用IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AER61
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹background:
AER61 is a 527 amino acid secreted protein that belongs to the glycosyltransferase 61 family and exists as three alternatively spliced isoforms. C3orf64 is encoded by a gene mapping to human chromosome 3p14.1. Chromosome 3 is made up of approximay 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3. 

Function:
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains (By similarity). 

Subcellular Location:
Endoplasmic reticulum lumen

Similarity:
Belongs to the glycosyltransferase 61 family. 

Database links:

Entrez Gene: 285203 Human

SwissProt: Q5NDL2 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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