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當(dāng)前位置：上海泛柯實(shí)業(yè)有限公司>>抗體>>一抗>>FITC標(biāo)記的磷酸化毛細(xì)血管擴(kuò)張性共濟(jì)失調(diào)癥突變蛋白抗體

FITC標(biāo)記的磷酸化毛細(xì)血管擴(kuò)張性共濟(jì)失調(diào)癥突變蛋白抗體

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FITC標(biāo)記的磷酸化毛細(xì)血管擴(kuò)張性共濟(jì)失調(diào)癥突變蛋白抗體產(chǎn)品介紹：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

詳細(xì)介紹

英文名稱Anti-phospho-ATM (Tyr170)/FITC
中文名稱FITC標(biāo)記的磷酸化毛細(xì)血管擴(kuò)張性共濟(jì)失調(diào)癥突變蛋白抗體
別    名ATM (Phospho-Tyr170); ATM (Phospho Y170); p-ATM (Tyr170); p-ATM (Y170); A-T mutated; A-T mutated homolog; AT complementation group A; AT complementation group C; AT complementation group D; AT complementation group E; AT mutated; AT protein; AT1; ATA; Ataxia angiectasia gene mutated in human beings; Ataxia angiectasia mutated; Ataxia angiectasia mutated gene; Ataxia angiectasia mutated homolog (human); Ataxia angiectasia mutated homolog; ATC; ATD; ATDC; ATE; ATM; ATM_HUMAN; DKFZp781A0353; Human phosphatidylinositol 3 kinase homolog; MGC74674; Serine protein kinase ATM; Serine-protein kinase ATM; Serine/threonine-protein kinase ATM; T cell prolymphocytic leukemia; Tefu; 1; 1, omere maintenance 1, homolog; O1; omere fusion protein; TPLL.
說 明 書100ul  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  細(xì)胞周期蛋白  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量370kDa
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human ATM around the phosphorylation site of Tyr170 [SV(p-Y)FR]
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 產(chǎn) 商BIOSS
產(chǎn)品介紹background:
ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia angiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).

Function:
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends.


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