西班牙Certest溶血性A鏈球菌抗體

廣州健侖生物科技有限公司

廣州健侖長期供應各種生物原料，主要代理品牌：西班牙Certest。

主要產品包括各種生物單克隆抗原抗體、重組蛋白。

西班牙Certest溶血性A鏈球菌抗體

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癌癥，雖然總是帶著危險的，但真正對生命造成威脅的是當癌細胞開始擴散到不同的領域和遍及全身時。現在，美國密蘇里大學(MU)的研究人員發現，由細菌用作通訊系統的一個分子可以被操縱來阻止癌細胞擴散。MU獸醫醫學院比較腫瘤學和表觀遺傳學實驗室的助理研究教授和副主任Senthil Kumar說，這個通訊系統可用于“告訴”癌細胞如何行動，甚至是死亡的命令。
“在感染期間，細菌會釋放出分子，使得它們能夠彼此‘交談’，” Kumar說，他了這項研究。“所述信號根據釋放分子的類型，告訴其他細菌繁殖，逃避免疫系統甚至停止蔓延。我們發現，如果我們將‘停止蔓延’的細菌分子引入癌細胞中，這些細胞不但會停止擴散，而且它們也將會開始死亡。”
這項研究發表于《PLoS ONE》雜志上，Kumar，以及合著者、MU獸醫醫學院的副教授杰弗里·布萊恩，使用稱為ODDHSL的細菌通訊分子用來治療在培養基中生長的人胰腺癌細胞。經過治療后，人胰腺癌細胞停止繁殖，未能遷移并開始死亡。
“我們之所以使用胰腺癌細胞，是因為這些細胞是發生在人體內zui強大的，侵襲性的以及難以殺滅的癌細胞，” Kumar說。“為了表明，這種分子不僅可以阻止癌細胞擴散，而且實際上也會導致它們死亡，這是非常令人興奮的。因為這個治療方法表明，其很有希望應用于像胰腺癌這種侵襲性的癌癥。我們相信它也可用于其他類型的癌細胞，以及我們實驗室正在其他類型的癌細胞中測試該治療方法。”
Kumar說，他研究的下一步是在動物和人體試驗發生前，尋找一個更有效的方式將該分子引入癌細胞中。
“現在，我們zui大的挑戰是，尋找一種有效的方式引入該分子，” Kumar說。“在這個時候，我們只能夠用這種分子在實驗室中治療癌細胞。現在，我們使用一個更好的方法來處理動物癌癥，看看這個治療是否真的有效。本研究的早期結果是有希望的。如果進一步的研究，包括動物實驗，都成功后，下一步是將這個方法應用于臨床試驗。”
預后良好的患者可幸免進行帶有嚴重副作用的侵入性治療，但不對侵入性腫瘤進行侵入治療或可導致死亡。癌癥之所以致命，在很大程度上是由于其發生了轉移，從一個器官或組織轉移到另一個器官或組織。癌癥致死絕大多數與轉移有關。
對于抗原抗體癌來說，被稱為“上皮間質轉化”的過程助推了這種轉移。上皮細胞系附著在與環境接觸的皮膚和胃腸道中。間質細胞是胚胎組織和結締組織中的一種細胞類型，其在那里形成非常松散的。腫瘤細胞失去成熟上皮細胞的特性(如附著于環境的能力)，獲得間質細胞的能力，使其能夠輕松地在細胞間流動并進入血液，從而遷移到遠處的器官和組織。

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【公司名稱】 廣州健侖生物科技有限公司
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【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

Cancer, while always dangerous, is a real threat to life as cancer cells begin to spread to different areas and spread throughout the body. Now researchers at the University of Missouri (MU) find that a molecule that bacteria use as a communication system can be manipulated to stop cancer cells from spreading. Senthil Kumar, professor and deputy director of assistant research at the MU Veterinary Medical School's Comparative Oncology and Epigenetics Laboratory, said the communication system can be used to "l" how cancerous cells act or even die.
"During infection, bacteria release molecules so they can talk to each other," Kumar said, who led the study. "The signal ls other bacteria to breed, escape the immune system, or even stop spreading, depending on the type of molecule released, and we found that if we introduce 'stop-going' bacterial molecules into cancer cells, they not only stop spreading, but they also It will start to die. "
The study, published in PLoS ONE, by Kumar and co-author Jeffrey Bryan, an associate professor at MU Veterinary Medical School, uses a bacterial communication molecule called ODDHSL to treat human pancreas that grows in culture cancer cell. After treatment, human pancreatic cancer cells stop multiplying, fail to migrate and begin to die.
"The reason we use pancreatic cancer is because these cells are the most powerful, aggressive and hard-to-kill cancer in the body," Kumar said. "It's very exciting to show that this molecule not only stops the spread of cancer cells but actually causes them to die, as this treatment shows promise for promising invasiveness like pancreatic cancer We believe it is also available for other types of cancer cells and our laboratory is testing the treatment in other types of cancer cells. "
Kumar said the next step in his research is to find a more effective way to introduce the molecule into cancer cells before animal and human trials occur.
"Now, our biggest challenge is to find an effective way to introduce that molecule," Kumar said. "At this point, we were only able to use this molecule to treat cancer cells in the laboratory, and now we use a better approach to treating animal cancers and see if the treatment is really effective. The early results of this study were Hopefully, if further research, including animal experiments, is successful, the next step is to apply the method to clinical trials. "
Patients with good prognosis can be spared aggressive treatment with serious side effects, but not invasive treatment of invasive tumors or can lead to death. The cancer is fatal, in large part because of its metastasis, its transfer from one organ or tissue to another organ or tissue. The vast majority of cancer death and metastasis.
For antigen-antibody cancers, a process called "epithelial mesenchymal transition" helps to promote this metastasis. Epithelial cell lines attach to the environment in contact with the skin and gastrointestinal tract. Stromal cells are a type of cell in embryonic tissue and connective tissue where they form a very loose connection. Tumor cells lose the characteristics of mature epithelial cells (e.g., attached to the capacity of the environment), the ability of mesenchymal cells obtained between, it can easily flow between the cells and into the bloodstream, so migrated to distant organs and tissues.